>Human_FXR
MGSKM-NLIEHSHLPTTDEFSFS---------ENLFGVLTEQVAGPLGQ-NLEVEPYSQY
SNVQFP-QVQPQI---SSSSYYSNLGFYPQQ-PEEWYSP-GIYELRRMPAETLYQGETE-
-VAEMP-VTKKPRMGA-SAGRIKGDE--LCVVCGDRA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAEC----LL
TEIQCKSKRLRKNVKQHAD--QTVNE-DSEGRDLRQVTSTTKSCR---------------
---EKTELTPDQQTLLHFIMDSYNKQR----------MPQEITNKI-LKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKL------
-------------PSGHSDLLEERIRNS------------------GISDEYITPMFSFY
KSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH
FACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ---
>Mouse_FXR
MVMQFQGLENPIQISLHHSHRLSGFVPDGMSVKPAKGMLTEHAAGPLGQ-NLDLESYSPY
NNVPFP-QVQPQI---SSSSYYSNLGFYPQQ-PEDWYSP-GIYELRRMPAETGYQGETE-
-VSEMP-VTKKPRMAAASAGRIKGDE--LCVVCGDRA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCREMGMLAEC----LL
TEIQCKSKRLRKNVKQHAD--QTVNEDDSEGRDLRQVTSTTKFCR---------------
---EKTELTADQQTLLDYIMDSYNKQR----------MPQEITNKI-LKEEFSAEENFLI
LTEMATSHVQILVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKL------
-------------PAGHADLLEERIRKS------------------GISDEYITPMFSFY
KSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKMYQPENPQH
FACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ---
>Rat_FXR
M-----NLIGPSHLQATDEFALS---------ENLFGVLTEHAAGPLGQ-NLDLESYSPY
NNVQFP-QVQPQI---SSSSYYSNLGFYPQQ-PEDWYSP-GLYELRRMPTESVYQGETE-
-VSEMP-VTKKPRMAASSAGRIKGDE--LCVVCGDRA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQDCRLRKCREMGMLAEC----LL
TEIQCKSKRLRKNVKQHAD--QTVNE-DSEGRDLRQVTSTTKLCR---------------
---EKTELTVDQQTLLDYIMDSYSKQR----------MPQEITNKI-LKEEFSAEENFLI
LTEMATSHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKL------
-------------PAGHADLLEERIRKS------------------GISDEYITPMFSFY
KSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQH
FACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ---
>Dog_FXR
MGSKM-NLIEHSHLPVTEEFSLS---------DNLFGVLTEQAAGPRGQ-NLDVEPYSQY
NNVQFP-QVQPQI---SSSSYYSNLGFYPQH-PEEWYSS-GIYELRRMPAETVYQGEIE-
-VAEIP-VTKKARMGA-SAGRIKGDE--LCVVCGDRA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLL
TEIQCKSKRLRKNVKQHAD--QTINE-DSEGRDLRQVTSTTKSCR---------------
---EKTELTPDQQNLLHYIMDSYSKQR----------MPQEIANKI-LKEEFSAEENFLI
LTEMATSHVQILVEFTKTLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKL------
-------------PAGHADLLEERIRKS------------------GISDEYITPMFSFY
KSVAELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQH
FACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ---
>Chicken_FXR
MGSEM-NLIGHPQLATADGFSLA-------EGPHLFGILSEPMSSPVQEAD--VSPYTQY
NSVPFP-QVQPQI---SSPPYYSNLGFYPPQ-HEEWYSP-GMYELRRIPSETFFTRETE-
-IMDIP-AAKKPRLGH-STGRMKGEE--LCVVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKNGGNCEMDMYMRRKCQECRLRKCKQMGMLAEC----LL
TEIQCKSKRLRKNVKQLPD--QTVNE-DNEGHDMKQVTSTTKMYR---------------
---EKVEFTPEQQNLLDYIMDSYSKQQ----------IPQEVSKKL-LHEEFSAEGNFLI
LTEMATSHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFSRKL------
-------------PTGHTVLLEERIRNS------------------GISDEFITPMFNFY
KSIGELKMTQEEYALLTAIVILSPDRQYIKDRESVERLQEPLLDILQKFCKLHHPDNPQH
FACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ---
>Frog_FXR
---------------------------------------------------------SPY
NHVQYP-SVHQSMTSSSSSPYHLNSNYYSQH-AEEWCAN-GIYDLKRIPSENLYSIDTD-
-IISLP-ATKKHRVSP-RVGRVKGDE--LCVVCGDNA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKNGGNCEMDMYMRRKCQECRLRKCKQMGMLAEC----LL
TEIQCKSKRLRKHAKPQSE--KSFQE-DIDGHETKQVTSTTKTNQ---------------
---ENTELTQEQMNLLQYVMDSHVKNR----------LPQSLATRLILQEDMGSDDNFVF
LTEMATRHVQILVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAELFNRKL------
-------------LERHTEVLEERIRKS------------------GISHDYINPMFHFY
KSVGELKMVEEEYALLTAVVILTPDRQYLKDKESVEKLQETFLHILEKICKRCHPDNPQH
FARLLGRLTELRTFSHHHADMLMSWRVNDHKFTPLLCEIWDVQ---
>Zebrafish_FXR
VGHDV-NVVGPLQIPPNDAFPLS-------ESSHFFDILAEQ-NSPLLQ-DQEVMPFTSY
PSMQYT-SVEPSM---SSPSYYSSQHCYSQYGAEEWYSPSAMFEMRKGPLDGGFDNELDE
SCPVIPTVCKRSRHAG-HSGKSKGEE--LCVVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYKCKSGGNCEMDMYMRRKCQECRLRKCKEMGMLAEC----LL
TEIQCKSKRLRKNTKASSD--ESIGDDVVDSRDPKQVVSTTKPSK---------------
---ENIELSQDQQALINYIVDAHNKHR----------IPQDMAKKL-LQEQFNAEENFLL
LTEMATSHVQVLVEFTKNIPGFQSLDHEDQIALLKGSAVEAMFLRSAQVFSKKL------
-------------PNGHTEVLEDRIRRS------------------GISEEFITPMFNFY
KSIGELQMMQEEHALLTAITILSPDRPYVKDQQAVERLQEPMLEVLRKICKLQHPQEPQH
FARLLGRLTELRTLNHHHAEMLESWRMSDHKFNPLLCEIWDVQ---
>Human_pFXRb
------------------------------------DILPEQISYQLHDTHFKKSPYCQY
SIAQFP-PALQSE---SLXNHFNTYRLDPQDSDGGQCGF-SSRELNKPTYVVAHDAEDG-
----YP-GIKRSRPTY-SSSRNKGQEE-FCVVCGDKASPSPYHYNALTCEGCKEIPMVKN
FKTFLLGFFQCSIXQNAVYSCRNGSHCEMDMYMRRKCQECRLKKYKAVGMLAEC----LL
TEIQCKLKRLQKNFKEKNHFYSNIKV-EEEGVDHSFLSSTTRPGK---------------
-IQESMELTEEEHQLINNIVAAHQKYT----------IPLEETNLY-LQEHTNPELSFLQ
LSETAVLHIRGLMNFTKGLPGFENLANEDQTALQKGSKTEVIFLHGAQLYSQKQ---SAS
ESSVRILNHSDYTPNCHNRSGDRSLICSMEKFYNEECPSTTLIVFWVLLKNLLXTLFYFY
KRMSKLDVTNTEYALLAA-TIVFSDRPCLKNKQYMENLXEPVLQILYKYSKMYHPEDPXH
FAHLIWKHTELRTLNYNHSEILSTWKTKDPKLATLLSEK-------
>Mouse_FXRb
--------MANTYVATSDGYYLA-------EPTQYYDILPEQFHYQLCDTDFQEPPYCQY
STAQFP-PALQSP---SLQSHFNTHGLDPQYSGGSWCGL-DARESGQSTYVVVHDDEDE-
----FP-GAQRCRAT--CSLRWKGQDDMLCMVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYSCKNGGHCEMDMYMRRKCQECRLKKCKAVGMLAEC----LL
TEIQCKSKRLRKNFKHGPALYPAIQV-EDEGADTKHVSSSTRSGKG--------------
-VQDNMTLTQEEHRLLNTIVTAHQKSM----------IPLGETSKL-LQEGSNPELSFLR
LSEVSVLHIQGLMKFTKGLPGFENLTTEDQAALQKASKTEVMFLHVAQLYGGKD---STS
GSTMRPAKPSAGTLEVHNPSADESV-HSPENFLKEGYPSAPLT---DITKEFIASLSYFY
RRMSELHVSDTEYALLTATTVLFSDRPCLKNKQHIENLQEPVLQLLFKFSKMYHPEDPQH
FAHLIGRLTELRTLSHSHSEILRMWKTKDPRLVMLFSEKWDLHSFS
>Rat_FXRb
--------MANTYVTTSDGYYLA-------EPTQYYDILPEQLHYQLCDTDFQEPPYSQY
STAQFP-PALQSP---SLQSHFSTYGLEPQYSGGSWCGL-DTRESSQSTYVVVHDDEDE-
----FP-GTQRCRPT--CSLRWKGQDE-LCMVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYSCKNGGHCEMDMYMRRKCPECRLKKCKAVGMLAEC----LL
TEIQCKSKRLRKSFKHRPTLSSAIQV-EDEGTDTKHVSSTSRSGKGARLFFHTVCPSVSL
QAQDDMTLTAEERRLLNTIVTAHRKSM----------VPVGEISAL-LQEYSNPELSFLR
LSEASILHANWLMKFTKGLPGFENLTAEDQTALQKESKTEVMFLHVAQLYGGRD---STS
GSTVRPAKPSAGTLEVHNHRGDECV-YSSENFFKEGYPSATLT---GITREFIASLSYFY
RRMRELNITDTEYALLTATTVLFSDRPYLKNKQHVENLQEPVLQLLFKYSKMYHPEDPQH
FAHLIGRLTELRTLSHSHSEILSTWKTKDPRLVMLFSEKWDLHSL-
>Dog_FXRb
--------MANTYVTTSDGYCLA-------EPVQYYDILPEQINYQLHDTDFQESPYCQY
STVQFP-SALQTQ---SLQSHFSSYSLDPQF-SGGECGF-GSYELSKPTFVVDHDAEDG-
----YS-GIKRSSLTH-SSIRLKRQEE-LCVVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYHCKNGGHCEMDMYMRRKCQECRLKKCKAVGMLAEC----LL
TEIQCKSKRLRKNFKQKNSFYSSIKV-EEEGVD-KLVSSTTRSGK---------------
-IKESVELTQEEHQLINNIVAAHQKYT----------IPLEETKKF-LQKYANPELSFLR
LSETVVLHLQGLIDFTKELPGFENLTIEDQTALRKGSKTEVMFLHGAQLYSQKQCLSSAS
ESTMRIADHSDHSLNFHNQSDNRNVIYSVETFHNEDCLPTTLT---GIAEEFITTLFYFY
RRMSELNITNIEYALLAATTVFFSDRPHLKNKRHVENLQEPILHILYKYSKIYHPEDLQH
FAHLIGRLTELRTLNHNYSEILSTWKAKDP----------------
>Chicken_FXRb
--------MANTFVTVPDGYCLA-------EPIQYYDVLPEHINYQLQDTDFQTAPYYQY
SSAQIPSPVLQSQ---PSQSHYSAYSLDSQYTDGQYI-I-SNCELSKPPFTASHLDDSG-
----FQ-ALKRPRLNH-SSLRLKGQEE-LCVVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYRCKNGGHCEMDMYMRRKCQECRLKKCRAVGMLAEC----LL
TEVQCKSKRLRKNFKQKSSFLCNIKL-EDEGVNSKHVSSTTRSGK---------------
-TVEKVELTPGEHQLLDHIVAAHQKYT----------IPLEEARKF-LQETTSPEESFLH
LSETAVVHVQVLVDFTKRLPGFESLASEDQIALLKGSTVEAMLLCSAQIYNQRI--SECQ
SSSESHIRRSDHTTCCHVPNLDKN-MYSIQMSHSEESPTSTTTT--GITEEFITALFYFY
RSMGELKVTETEYALLVATTVLFSDRPLLRNKRHVEELQEPFLGILYKYSKIHHPEDPQH
FARLIGRLTQLRTLNHTHAEVLVTWRTKDPRLTALLCEVWELH---
>Frog_FXRb
--------MANSYVTVSDAYCLA-------EPLSYYDVLPDHINYQLPDSEFQTASCCQY
TNMAYS-PGLQSP---SSQCHYTSYGLEAAYGDGQYL-L-STCELSKQTTLMTHGVDEV-
----YP-TMKRPRVSH-ASIRMKGHEE-LCVVCGDKA--SGYHYNALTCEGCK-------
------GFFRRSITKNAVYRCKNGGHCEMDMYMRRKCQECRLKKCKAVGMLAEC----LL
TEVQCKSKRLRKNCKQNNSMLSNVKV-EDEGSDSRHVSSTTKPTK---------------
-LSSQPELTAEECKLIDHIVTAHQKCG----------IPLDDLKIF-VKESADPEEIFYH
FSEAAVLHVQAFVEFTKRLPGFEMLDHEDQIALLKGSTVEAMLLRSAQIYNLPV------
-------------MGCSLQTTEVYFYYVFKIFIKHFSFFSFVI---DLTEEFITPLFKFF
RSMGSLNVTEAEYALLSAVTVFFSDRPLLQNKPHVEKLQEPLLGILHKYSKLYHPEDPQH
FARLIGRLTELRTLNHNHSEVLISWKARDTKLTPLLYGFWNL----
>Human_LXRa
------------------------------------------------------------
----MP------------------------HSAGGTAGV-GL-EAAEPTALLTRAEPPS-
----EPTEIRPQKRKKGPAPKMLGNE--LCSVCGDKA--SGFHYNVLSCEGCK-------
------GFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREEC----VL
SEEQIRLKKLKRQE-------------EEQAHATSLPPRASSPPQ---------------
---ILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPD--PHSREARQQRFAH
FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYN---------
-------------PGSESITFLKDFSYNREDFAKA-----------GLQVEFINPIFEFS
RAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLM
FPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE--